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Provigil is a central nervous system (CNS) stimulant and wakefulness-promoting agent. Its active ingredient is Modafinil. This medication is primarily used to treat narcolepsy, obstructive sleep apnea, and shift work sleep disorder.

Its dosage form is oral tablets, available as Provigil 100mg and Provigil 200mg.

How Does Provigil Work?

Modafinil’s exact mechanism of action is unclear. However, many believe it affects the brain chemicals responsible for sleep and wakefulness.

It’s important to note that this medication doesn’t treat the underlying disorder. It only makes patients feel more awake. Also, Provigil doesn’t replace other treatments for narcolepsy or OSA. You should continue these while taking Provigil.

How to Take Provigil

You must take Modafinil exactly as your healthcare provider has directed. Read all medication guides, instruction sheets, and other materials provided to you. Please ask your doctor or pharmacist if you have any questions.

Provigil is typically taken once daily. If you have daytime sleepiness due to narcolepsy or OSA, take it in the morning when you wake up. To treat work-time sleep disorders, take Provigil one hour before your work shift.

You can take the tablet with or without food. You’ll typically take Provigil for up to 12 weeks. Please consult your caregiver if you experience excessive sleepiness that persists even while taking this medication.

Warning! Taking Provigil does not substitute for getting sufficient sleep. The drug may be habit-forming. Do not share it with another person, particularly someone with a history of addiction or drug abuse.

Provigil Dosage

• Typical adult Provigil dose for Narcolepsy: 200mg orally in the morning—daily.
• The usual adult dose for OSA is Provigil 200mg orally daily in the morning.
• Typical adult dose for Shift Work Sleep Disorder: Provigil 200mg orally every day, an hour before starting work shift.

Taking Provigil for OSA

If you’re taking Provigil for sleepiness caused by OSA (obstructive sleep apnea), you may as well use a CPAP (Continuous Positive Airway Pressure) machine. Your doctor will decide if you need both treatments. Do not stop using your CPAP machine while sleeping unless the physician says so.

Missed Dose & Overdose

Skip the missed dose. Do not take extra medicine the next day to compensate for the missed dose. You should skip Provigil if you remember your dose, but it’s almost bedtime, or you don’t plan to be awake for several hours.

In case of an overdose, please seek emergency medical attention.

Provigil Side Effects

Commonly reported mild side effects of Provigil include:

• Headache
• Nausea
• Dizziness
• Diarrhea
• Anxiety/nervousness/agitation
• Upper respiratory tract infection
• Dry mouth
• Trouble sleeping
• Poor appetite

Please stop taking Provigil and call your healthcare provider if you experience severe side effects, including:

• Fever
• Signs of allergic reaction, such as an itchy skin rash, swelling on your face, throat, or difficulty breathing
• Easy bruising/bleeding
• Depression/mood changes/hallucinations
• Chest pain/pounding or irregular heartbeat

The above is not a complete list of side effects. If you experience new side effects, let your doctor know.

What to Know Before Taking Provigil

Provigil is not approved for use by persons younger than 17 years old.

This medicine may affect your thinking or reactions. You must be careful if you drive or do anything requiring maximum alertness. Avoid hazardous activities until you’re sure how this drug affects your wakefulness.

You should also not drink alcohol while using Provigil.

To ensure Provigil is safe for you, let your doctor know if you have any of the following medical conditions:

• Angina (chest pain)
• If you’ve had an allergic reaction while taking Modafinil or armodafinil.
• A history of drug addiction or alcoholism
• A history of psychosis or mental illness
• Heart disease, high blood pressure, or a history of heart attack
• Kidney disease
• Liver issues, including cirrhosis

Birth Control, Pregnancy, & Breastfeeding

Provigil may affect the effectiveness of birth control drugs. Talk to your doctor to recommend adequate birth control treatment while taking Provigil.

It’s best to avoid Modafinil if you’re pregnant or intend to become pregnant. This medicine may harm an unborn baby. It’s still unknown whether Provigil makes its way into breast milk and hurts a nursing baby.

Other Drugs that May Interact with Provigil

Provigil may interact with other medicines, causing serious side effects or affecting the way they work. For this reason, you should tell your doctor about every medicine you take. These include prescription, over-the-counter drugs, herbal supplements, and vitamins.

Especially let your healthcare provider know if you take:

• Contraceptives, cyclosporine, triazolam, and midazolam
• Phenytoin, propranolol, diazepam, clomipramine, and omeprazole
• Warfarin
• Isocarboxazid, selegiline, and other monoamine oxidase (MAO) inhibitors

Note: This is not a complete list of interactions. Read the Provigil prescription information for more information.

Provigil Storage

You should store Provigil at room temperature in a cool and dry place. It goes without saying that you should keep the medication out of the reach of others.